OPIOIDES SINTÉTICOS NO PEPTÍDICOS CON PROPIEDADES INMUNOMODULADORAS Y ANTITUMORALES

Diana Caballero-Hernández, Reyes Tamez-Guerra, Cristina Rodríguez-Padilla, Patricia Tamez- Guerra, Richard J. Weber, Ricardo Gómez Flores

Resumen


El diseño y síntesis de opioides no peptídicos con un perfil farmacológico especifico representa un prometedor campo de estudio, así como una fuente de nuevos compuestos con potencial aplicación terapéutica. En este trabajo hemos evaluado una serie de opioides sintéticos no peptídicos por sus propiedades inmunoreguladoras y antitumorales. Los resultados de este estudio apoyan la noción según la cual los opioides sintéticos, en la misma forma que los naturales, poseen propiedades bioreguladoras de importancia. Mas aun, las observaciones obtenidas con el
agonista opioide SNC 80, sugieren para este compuesto un gran potencial clínico como analgésico no inmunosupresor, y/o agente antitumoral.


Palabras clave: SNC80, antiproliferativo, inmunoestimulante, proinflamatorio   SNC80, antiproliferative, immunostimulating, pro-inflammatory


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    Copyright (c) 2004 Diana Caballero-Hernández, Reyes Tamez-Guerra, Cristina Rodríguez-Padilla, Patricia Tamez- Guerra, Richard J. Weber, Ricardo Gómez Flores

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    RESPYN, Revista Salud Pública y Nutrición, es una revista electrónica, con periodicidad trimestral, editada y publicada por la Universidad Autónoma de Nuevo León a través de la Facultad de Salud Pública y Nutrición. Domicilio de la Publicación: Aguirre Pequeño y Yuriria, Col. Mitras Centro, Monterrey, N.L., México CP 64460. Teléfono: (81) 13 40 48 90 y 8348 60 80 (en fax). E-mail: respyn.faspyn@uanl.mx , URL: http://www.respyn.uanl.mx/. Editor Responsable: Dr. en CS. Esteban Gilberto Ramos Peña. Reserva de derechos al uso exclusivo No. 04-2014-102111594800-203, de fecha 21 de octubre de 2016. ISSN 1870 - 0160. Ambos otorgados por el Instituto Nacional del Derecho de Autor. Registro de marca ante el Instituto Mexicano de la Propiedad Industrial: No. 1,183,059. Responsable de la última actualización de este número Dr. Esteban Gilberto Ramos Peña, Cd. Universitaria, San Nicolás de los Garza, N.L., México.