Microbiota intestinal, sobrepeso y obesidad

Autores/as

  • Noé González-Gallegos Centro Universitario del Norte de la Universidad de Guadalajara.
  • Yesica Sughey González-Torres Centro Universitario de los Altos de la Universidad de Guadalajara.
  • Luis Felipe Padilla-Durán Centro Universitario del Norte de la Universidad de Guadalajara.

DOI:

https://doi.org/10.29105/respyn16.3-4

Resumen

Introducción: En la actualidad a pocos asombra el hecho de que la microbiota intestinal juega un papel esencial en el desarrollo del sobrepeso y la obesidad. Cada día los mecanismos de la teoría del microbioma obeso están más claros, estos incluyen la regulación del sistema inmune, la competencia con el enterocito por las calorías de la dieta, su papel en la regulación de la función endocrina del sistema gastrointestinal que controla el apetito y, también muy fascinante su mediación a nivel epigenético. Objetivo: En este ensayo discuten estos aspectos, así como algunas recomendaciones alimentarias basadas en los conocimientos actuales para el control del peso a través de la promoción de un microbioma más equilibrado. Conclusiones: Los mecanismos de acción a través de los cuales el microbioma puede contribuir al sobrepeso y la obesidad incluyen un aumento de la captación energética a nivel intestinal, incremento de deposición de lípidos en el tejido adiposo y activación de la inflamación sistémica. Se visualizan en el tratamiento de la obesidad el uso de probióticos y prebióticos involucrados en la regulación de la microbiota intestinal.

ABSTRACT

Introduction: At present the fact that the gut microbiome plays an essential role in the development of overweight and obesity to few ones seems surprising. The mechanisms of the theory of obese microbiome are clearer every day. Some of these mechanism include a regulations over the immune system, furthermore, the gut microbiome influences both sides of the energy-balance equation by contributing to nutrient absorption and regulating host genes that affect adiposity. Another mechanism for promoting weight gain is based on the endocrine role of gastrointestinal system on hunger, satiety, and food intake. Objective: This paper summarizes all these aspects, and describes some evidence-based recommendations to improve the equilibrium of gut microbiome with the goal of to get loss weight. Conclusions: The mechanisms of action across which the microbioma can contribute to the overweight and the obesity include an increase of the energetic capture to intestinal level, increase of deposition of lipids in the adipose fabric and activation of the systemic inflammation. In the treatment of the obesity, the regulation of the gut microbiota notes the use of probiotics and prebiotics involved

Palabras clave: sobrepeso, obesidad, microbioma intestinal, overweight, obesity, gut microbiome

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Angelakis, E., Armougom, F., Carrière, F., Bachar, D., Laugier, R., Lagier, J. C., & Raoult, D. (2015). A metagenomic investigation of the duodenal microbiota reveals links with obesity PLoS One (Vol. 10).

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., & Gordon, J. I. (2004). The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences of the United States of America, 101(44), 15718-15723.

Bjursell, M., Admyre, T., Göransson, M., Marley, A. E., Smith, D. M., Oscarsson, J., & Bohlooly-Y, M. (2011). Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet. American Journal of Physiology-Endocrinology and Metabolism, 300(1), E211-E220.

Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R. G., & Tuohy, K. M. (2007). Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxinaemia. Diabetologia, 50(11), 2374-2383.

Chow, J., Tang, H., & Mazmanian, S. (2011). Pathobionts of the gastrointestinal microbiota and inflammatory disease. Current opinion in immunology, 23(4), 473-480.

Cox, L. M., Yamanishi, S., Sohn, J., Alekseyenko, A. V., Leung, J. M., Cho, I., & Rodriguez, J. G. Z. (2014). Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell, 158(4), 705-721.

Drissi, F., Raoult, D., & Merhej, V. (2016). Metabolic role of lactobacilli in weight modification in humans and animals. . Microbial pathogenesis. Disponible en: http://www.sciencedirect.com/science/article/pii/S0882401015301522

Ehrlich, S. D. (2011). Gut microbial communities viewed through the MetaHIT microscope. Paper presented at the 2nd International Symposium Microbes for Health, Paris.

Esquivel Flores, M. G. (2017). Microbiota intestinal: el universo que nos habita. Cuadernos de Nutrición, 40(3), 107-114.

Everard, A., Lazarevic, V., Gaïa, N., Johansson, M., Ståhlman, M., Backhed, F., . . . Cani, P. D. (2014). Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity. The ISME Journal, 8(10), 2116-2130.

Goodman, A. L., Kallstrom, G., Faith, J. J., Reyes, A., Moore, A., Dantas, G., & Gordon, J. I. (2011). Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice. Proceedings of the National Academy of Sciences, 108(15), 6252-6257.

Gotteland, M. (2013). El papel de la microbiota intestinal en el desarrollo de la obesidad y de la diabetes de tipo-2. Rev Chil Endocrinol Diabetes, 6(4), 155-162.

Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001). Molecular analysis of commensal host-microbial relationships in the intestine. Science, 291(5505), 881-884.

Karasu, S. R. (2016). The obesities an overview of convergent and divergent paradigms. American Journal of Lifestyle Medicine, 10(2), 84-96.

Le Barz, M., Anhê, F. F., Varin, T. V., Desjardins, Y., Levy, E., Roy, D., . . . Marette, A. (2015). Probiotics as complementary treatment for metabolic disorders. Diabetes & metabolism journal, 39(4), 291-303.

Morales, P., Brignardello, J., & Gotteland, M. (2010). La microbiota intestinal: Un nuevo actor en el desarrollo de la obesidad. . Revista médica de Chile, 138(8), 1020-1027.

Musso, G., Gambino, R., & Cassader, M. (2009). Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Progress in lipid research, 48(1), 1-26.

Park, S., & Bae, J. H. (2015). Probiotics for weight loss: a systematic review and meta-analysis. Nutrition Research, 35(7), 566-575.

Phillips, I., Casewell, M., Cox, T., De Groot, B., Friis, C., Jones, R., . . . Waddell, J. (2004). Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data. Journal of Antimicrobial Chemotherapy, 53(1), 28-52.

Raoult, D. (2016). Microbiota, obesity and malnutrition. Microbial pathogenesis. Disponible en: http://www.sciencedirect.com/science/article/pii/S0882401016300523

Requena, T., Barroso, E., T, G.-C., Bustos, I., Martínez-Cuesta, M. C., & Peláez, C. (2013). Papel de la microbiota intestinal en la obesidad humana. Empleo de prebióticos y probióticos. Alimentación, Nutrición y Salud, 20(2), 25-30.

Shojima, N., Ogihara, T., Inukai, K., Fujishiro, M., Sakoda, H., Kushiyama, A., & Horike, N. (2005). Serum concentrations of resistin-like molecules β and γ are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow. Diabetologia, 48(5), 984-992.

Stephani, J., Radulovic, K., & Niess, J. (2011). Gut microbiota, probiotics and inflammatory bowel disease. Archivum immunologiae et therapiae experimentalis, 59(3), 161-177.

Tavares da Silva, S., Araujo dos Santos, C., & Bressan, J. (2013). Intestinal microbiota; relevance to obesity and modulation by prebiotics and probiotics. Nutrición Hospitalaria, 28(4), 1039-1048.

Thuny, F., Richet, H., Casalta, J. P., Angelakis, E., Habib, G., & Raoult, D. (2010). Vancomycin treatment of infective endocarditis is linked with recently acquired obesity. PLoS One, 5(2).

Tsai, F., & Coyle, W. J. (2009). The microbiome and obesity: is obesity linked to our gut flora? Current gastroenterology reports, 11(4), 307-313.

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006). An obesity-associated gut microbiome with increased capacity for energy harvest. Nature, 444(7122), 1027-1031.

Turner, J. R. (2009). Intestinal mucosal barrier function in health and disease. Nature Reviews Immunology, 9(11), 799-809.

Valsecchi, C., Tagliacarne, S. C., & Castellazzi, A. (2016). Gut Microbiota and Obesity. Journal of Clinical Gastroenterology, 50(Supp 2), S157-S158.

Vanderhoof, J. (2016). Microbiota And Obesity. Journal of Pediatric Gastroenterology and Nutrition, 63(1S), S46.

White, N. D. (2015). Gut microbiota and obesity potential therapeutic targets and probiotic treatment. American Journal of Lifestyle Medicine. Disponible en: http://ajl.sagepub.com/content/early/2015/11/23/1559827615619586.full doi:1559827615619586

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Publicado

2017-10-11

Cómo citar

González-Gallegos, N., González-Torres, Y. S., & Padilla-Durán, L. F. (2017). Microbiota intestinal, sobrepeso y obesidad. RESPYN Revista Salud Pública Y Nutrición, 16(3), 23–28. https://doi.org/10.29105/respyn16.3-4

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