FORMAS FARMACÉUTICAS Y SU ADMINISTRACIÓN ¿CUALES NO DEBEN PARTIRSE O TRITURARSE?
Abstract
Cuando un paciente se dirige a una farmacia y presenta una receta recibe a cambio de ésta principios activos que se presentan en diferentes formas farmacéuticas. La elaboración de las formas farmacéuticas es de suma importancia para garantizar una utilización racional de los principios activos adaptándolos a la vía de administración adecuada. La mayoría de los medicamentos usados hoy en día se encuentran en forma sólida, por lo que es común la práctica de triturar tabletas y mezclarlas con alimentos antes de administrarlas, especialmente en establecimientos institucionales de atención médica. Generalmente, cualquier tableta que está cubierta, lo está por una razón y no debe ser triturada. Las formulaciones con cubierta entérica o de
liberación prolongada nunca deben ser trituradas debido a que pueden ocasionar irritación de la mucosa del tracto digestivo y generar efectos secundarios o toxicidad.
Palabras clave: Formas farmacéuticas, triturar. partir
pharmaceutical forms, crush, splitting
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References
Aiache, J.M., S. Aiache and R. Renoux. 1996. Introducción al estudio del medicamento. 1º Edición. Editorial MASSON, España
Secretaría de Salud 2002. Ley General de Salud. Tomo 1 y 2 Ed. Porrua.
Aiache, J.M., et. al., Op. cit.
Idem.
Secretaria de Salud 2000. Farmacopea de los Estados Unidos Mexicanos. SSA/Comisión Permanente de la FEUM. 7a. Ed. México.
Mobley, C. 2003. Anatomical and physiological considerations for pharmacy compounding. Drug Topics. 64- 72
Aiache, J.M., et. al. , Op. cit.
Mobley, C., Op. cit
Bruning, W.C. and J. Jr. Setaro. 1983. Oral solid dosage forms: be sure before you crush them. Pharmacy Times. pp 28-30
Porter, S.C. 2000. Coating of Pharmaceutical Dosage Forms en Remington: The Science and Practice of Pharmacy 20th edition Lippincott Williams & Wilkins
Stanford University/School of Medicine 2002 Pill-splitting can yield cost savings on common prescription drugs, Stanford researchers find (http://mednews.stanford.edu/releases/2002/august/pillsplitting.html)
Marriott, J.L. and R.L.. Nation. 2002. Splitting tablets. Aust Prescr. 25: 133-135
Bruning, W.C. and J. Jr. Setaro, Op. cit.
Mitchell, J.F., 1996. Oral dosage forms that should not be crushed. Hospital Pharmacy. 31: 27-37
Mitchell, J.F., 2000. Oral dosage forms that should not be crushed: 2000 updated, Hospital Pharmacy. 35 (Suppl 5): 553-557
Lacy, Ch. F., L. L. Armstrong, M. P. Goldman 2000. Drug Information Handbook: Pocket, 2000-2001 Lexi- Comp, Inc.; 5th edition (June 15, 2000); 1213 pages
Drugs that should not be crushed. 1999. RN; 62 (Suppl 8): 24ac2-24ac4
Bachynsky, J., Ch. Wiens and K. Melnychuk. 2002. The practice of splitting tablets cost and therapeutic aspects. Pharmacoeconomics. 20 (Suppl 5): 339-346
Wordell, D.C. 1988. Should you crush that tablet. Nursing. 1: 48-49
Melgoza, L.M., L. Contreras, S. Rodríguez y M. González. 2002. Sistemas matriciales de liberación controlada. Revista Mexicana de Ciencias Farmacéuticas. 33 (Supl 4): 58-66
Díaz, J.J., A.R. López. 2002. Excipientes de liberación prolongada para la vía oral. Informacéutico. pp23- 29
Miller, D., H. Miller. 2000. To crush or not to crush? Nursing. 30 (Suppl 2): 51-54
Stuart, M. 2003. To crush or not to crush? General Practitioner. 82
David, U. and E. Etchells. 2005. Avoid the crush: hazards of medication administration in patients with dysphagia or a feeding tube. CMAJ. 172 (Suppl 7): 871-872
Porter, S.C.. Op. cit.
Diccionario de Especialidades Farmacéuticas PLM.2004 50 ed. Ediciones PLM, México
Marriott, J.L. and R.L.. Nation, Op. cit
Bachynsky, J., et. al, Op. cit
Winckler, J.D. 2004. Tablet splitting appropriateness for patients. J. Am Pharm Assoc. 44 (Suppl 3): 324- 325.
Schellhase, E. and K. Hardin. 2003. Development and implementation of a tablet splitting education program in a veterans affairs medical center. Hospital Pharmacy. 38 (Suppl 5): 453-457
Cohen, R.M. and N.M Davis. 1994. Improperly crushing oral dosage forms. American Pharmacy. 34(Suppl 9): 21
Sedrati, M., P. Arnaud, E. J Montan and F. Brion. 1994. Splitting tablets in half. Am J Hosp Pharm. 51: 548- 552
Fischbach, M. S., J. Gold, M. Lee, J. Jergal, G. Litner and P. Rochon. 2001. Pill-splitting in a long-term care facility. CMAJ. 164 (Suppl 6): 785-786
Carr-Lopez, S., M. Mallet and T. Morse. 1995. The tablet splitter: barrier to compliance or cost-saving instrument? AJHSP. 52 (Suppl 23): 2707-2708
Peek B. and A. Al-Achi. 2002. Accuracy of tablet splitting by elderly patients. JAMA..288 (Suppl 4): 451- 452
Farell, N.C., T. Cookson and S. Scanton. 1999. Relationship between tablet splitting and compliance, drug acquisition cost, and patient acceptance. AJHSP. 56 (Suppl 24): 2542-2545
Stanford University/School of Medicine, Op. cit.
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