EFECTO DE LA ACTIVIDAD ANTIESPASMODICA DEL EXTRACTO METANOLICO DEL ALGA Oedogonium capillare (Linn) Kuetz SOBRE ILEON DE RATA WISTAR
Abstract
El alga Oedogonium capillare (Linn.) Koetz, se evaluó el efecto antiespasmódico de los extractos de metanol, cloroformo y hexano, en una preparación para órgano aislado in Vitro sobre íleon de rata Wistar, utilizando acetilcolina y cloruro de potasio. Se determinó IC50 para cada uno de ellos. El extracto metanólico tuvo efectos relajantes significativos sobre el íleon utilizado a diferencia de los otros extractos clorofórmico y hexánico que no tuvieron actividad. También el extracto de metanol es capaz de inhibir la contracción inducida con KCl y la acetilcolina, este efecto antiespasmódico puede explicar el uso que se le da en la medicina tradicional.
Abstract
The antispasm effect of methanol, chloroform and hexane extracts of the algae Oedogonium capillare (Linn.) Koetz was evaluated in an in Vitro preparation for an isolated organ. This was tested on the ileum of Wistar rats using acetylcholine and potassium chloride. For each of them, IC50 was determined. The methanol extract had a significant relaxation effect on the ileum in contrast with the other chloroform and hexane extracts which showed no activity. The methanol extract showed also a capability to inhibit contractions induced with KCl and acetylcholine; this antispasm effect might account for the use of this algae in traditional medicine.
Palabras clave: actividad antiespasmódica, extracto metanólico, Oedogonium capillare.
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References
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