Una revisión de estudios experimentales sobre hepatotoxicidad relacionada a la exposición por acrilamida
DOI:
https://doi.org/10.29105/respyn23.2-780Palabras clave:
Hígado, Estrés oxidativo, AcrilamidaResumen
Introducción: La acrilamida es un compuesto tóxico que puede formarse en alimentos preparados a altas temperaturas, en exposición crónica provoca neurotoxicidad, genotoxicidad, y puede ser carcinógena. El hígado es el principal encargado de su metabolismo, la acrilamida y sus metabolitos pueden producir daños e inflamación crónica hepática que pueden desencadenar patologías graves. Objetivo: Analizar la información más reciente con relación a la hepatotoxicidad asociada a la ingesta de acrilamida. Material y Método: Se realizó una revisión hemerográfica en PubMed, ScienceDirect y Google Académico, utilizando términos MeSH: liver, toxicity, acrylamide, oxidative stress, Wistar Rat y Booleanos: “and”, “or”, “not” considerando artículos a partir del 2018, seleccionando los que describieran en su contenido datos relacionados las palabras clave. Resultados: La hepatotoxicidad por exposición a acrilamida está relacionada a alteraciones de biomarcadores de estrés oxidativo, cambios en metabolómica y en procesos de autofagia, activación del inflamasoma, y modificaciones estereológicas e histológicas. Conclusión: La información actualizada demuestra que a la hepatotoxicidad asociada a acrilamida le subyacen diversos mecanismos celulares en los que generalmente está involucrado el estrés oxidativo, por ello el abordaje de estrategias para entender y disminuir el impacto de la exposición debe considerar dichos aspectos.
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Derechos de autor 2024 María-Guadalupe Martínez-Otríz, Luis-Carlos García-Palafox, Ángeles Martínez-Toto, Ruben Ruíz-Ramos, MARÍA-GUADALUPE SÁNCHEZ-OTERO
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