THE ROLE OF LEPTIN IN OBESE CHILDREN
Resumen
Pediatric obesity is a major concern for clinicians. It represents arisk factor for several diseases later in life (1) .The current
increase in the prevalence of pediatric obesity has fostered a
multidisciplinary discourse on the most appropriate strategy for
reducing this epidemic. It is estimated that obesity currently
affects 25% of children in the United States(2).
In our opinion, much more attention should be given to prevention
and the development of preventive strategies at all ages. To
attempt the prevention of childhood obesity, it would be clinically
useful to have a predictive parameter or set of parameters with
which to define an "at risk" state of obesity.
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Pi Sunyer FX. 1990; Health implications of obesity. Am J. Clin. Nutr. 2: 15995-16035.
Troiano RP, KM Flegal and RJ Kuesmarski 1995. Overweight prevalence and trends for children
and adolescents; Arch. Pediatr. Adolesc. Med, 149: 1085-1091.
Zhang Y, R Proenca, M. Maffei, M Barone M, L. Leopold L and JM Friedman 1994. Positional
cloning of the mouse obese gene and its human homologue. Nature 372: 425-431.
Falorni A, V. Bini, D. Molinari, F Papi, F. Celi, G Di Stefano, MG Berioli, ML Bacosi and G
Contessa. 1997 Leptin serum levels in normal weight and obese children and
adolescents:relationship with age, sex, pubertal development, body mass index, and insulin;
International Journal of Obesity, 21: 881-890.
Byrnes SE, LA Baur, M Bermingham, K Brock and K Steinbeck 1999. Leptin and total cholesterol
are predictors of weight gain in pre-pubertal children; International Journal of Obesity 23: 146-150.
Holub M, K Zwiauer, C Winkler, B Dillinger-Paller, E Schuller, E Schober E, S Stöckler-Ipsiroglou,
W Patsch and W Strobl.1999 Relation of plasma leptin lipoproteins in overweight children
undergoing weight reduction, International Journal of Obesity, 23: 60-66.
Zadik Z, I Wittenberg, N Segal, Y Altman, A Zung., V Gross V and R Reifen 2000.
Interrelationship between insulin, leptin and growth hormone in growth hormone-treated children;
International Journal of Obesity 25: 538-542.
Johnson MS, TT Huang, R Figueroa-Colon , JH Dwyer and MI Goran 2001 Influence of leptin on
changes in body fa
t during growth in African American and White children; Obesity Research Vol. 9
No. 10, 593-598.
Verdich C, S Toubro, B Buemann, JJ Holst, J Bülow, L Simonsen, SB Sondergaard, NJ
Christensen and A Astrup 2001 Leptin levels are associated with fat oxidation and dietary-induced
weight loss in obesity; Obesity Research, Vol. 9 No. 8, 452-461.
Byrnes, SE., et. al., Op cit..
Sudi K M, S Gallistl. G Weinhandl, W Muntean and MH Borkenstein 2000. Relationship between
plasminogen activitor inhibitor-1 antigen, leptin, and fat mass in obese children and adolescents;
Metabolism Vol. 49, No. 7: 890-895.
Chu NF, DJ Wang, SM Shieh and EB Rimm 2000. Plasma leptin concentrations and obesity in
relation to insulin resistance syndrome components among school children in Taiwan-The Taipei
Children Heart Study. International Journal of Obesity 24: 1265-1271.
Hodge AM, MP de Courten, GK Dowse, PZ Zimmet, GR Collier,. H Gareeboo, P Chiston, D
Fareed, F Hemraj. KG Alberti and J Tuomilehto 1998.Do leptin levels predict weight gain ? A 5-year
follow-up study in Mauritius. Mauritius Non-communicable Disease Study Group.Obesity Research
: 319-325
Nagy TR, SL Davis, GR Hunter, B Darnell B and RL Weinsier 1998. Serum leptin
concentrations and weight gain in postobese, postmenopausal women. Obesity Research 6: 257-
Lissner L, C Karlsson, AK Lindroos, L Sjostrom, B Carlsson, L Carlsson, and C
Bengtsson. 1999. Birth weight, adulthood BMI, and subsequent weight gain in relation to leptin
levels in Swedish women. Obesity Research ; 7: 150-154.
Di Stefano G, V Bini, F Papi, F Celi, G Contessa, MG Berioli, ML Bacosi and A Falorni 2000
Leptin serum concentrations predict the responsiveness of obese children and adolescents to
weight excess reduction program; International Journal of Obesity , 24: 1586 -1591
Johnson MS., et. al., Op cit..
Byrnes SE,. et. al., Op cit..
Zimmet P and KGMM Alberti 1996. Leptin is it important in diabetes ? Diabetic Med, 13: 501-
Chu, NF et. al., Op cit..
Zadik, Z., et. al., Op cit.
Gutin B, L Ramsey, P Barbeau, W Cannady, M Ferguson, M Litaker M and O Scott 1999
Plasma leptin concentrations in obese children: changes during 4-months periods with and without
physical training; Am. J. Clin Nutr, 1999; 69: 388-394
Holub M et. al., Op cit
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