CRITERIOS DE CALIDAD DE LOS MICROORGANISMOS PROBIÓTICOS Y EVIDENCIAS SOBRE EFECTOS HIPOCOLESTEROLÉMICOS

Authors

  • Fabián González Rivas Departamento de Ciencia Animal y de los Alimentos, Facultad de Veterinaria, Universitat Autónoma de Barcelona (Barcelona, España) Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León. (Nuevo León, México)
  • Blanca Edelia González-Martínez Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León. (Nuevo León, México)

Abstract

En los últimos años se ha observado un desarrollo muy importante del mercado de los alimentos funcionales que portan microorganismos vivos. Estos productos soy muy interesantes desde el punto de vista económico, ya que en la mayoría de los casos son leches fermentadas, que al contener algún microorganismo adicional,
se les puede incrementar el precio dejando un interesante margen al productor. Sin embargo en muchos casos estos nuevos microorganismos no cumplen unos mínimos aspectos de calidad que aseguren su funcionalidad y efectos beneficiosos en el consumidor, por lo que este paga más para obtener lo mismo. Esta revisión pretende plantear cuales son, según los conocimientos científicos actuales, las pruebas de calidad que estos microorganismos deben superar antes de ser considerados como probióticos y por tanto incluidos en alimentos y publicitados como funcionales. Siempre partiendo de la base que han superado las pruebas
previas de seguridad, básicamente las de inocuidad. A su vez en la presente revisión se plantea la funcionalidad de estos microorganismos haciendo hincapié en la reducción del colesterol plasmático.


Palabras clave: Probióticos, pruebas de calidad, colesterol.

Probiotics, quality test, cholesterol

Downloads

Download data is not yet available.

References

Anonymous. The Columbia Encyclopedia, 6th Ed. 2001. New York, Columbia University Press.

Meurman,J.H. 2005, Probiotics: do they have a role in oral medicine and dentistry?: Eur J Oral Sci, v. 113, p. 188-196.

Guarner F, G. Perdigon ,G. Corthier,S. Salminen ,B. Koletzko and L. Morelli 2005. Should yoghurt cultures be considered probiotic? Br J Nutr. Jun;93(6):783-6

Fuller,R. 1989, Probiotics in man and animals.: J.Appl.Bacteriol., v. 66, p. 365-378.

Stanton,C, P Ross, G F Fitzgerald and D Van Sinderen 2005. Fermented functional foods based on probiotics and their biogenic metabolites.: Current Opinion in Biotechnology, v. 16, p. 198-203.

Idem.

Isolauri,E, S Rautava, M Kalliomaki, P Kirjavainen and S Salminen, 2002, Role of probiotics in food hypersensitivity.: Current Opinion Allergy Clin Immunol., v. 2, p. 263-271.

Salminen,S.P., M Gueimonde and E Isolauri, 2005, Probiotics that modify disease risk.: J.Nutr., v. 135, p. 1294-1298.

Saxelin,M, S Tynkkynen, T Mattila-Sandholm and W M de Vos 2005, Probiotic and other functional microbes: from markets to mechanisms.: Current Opinion in Biotechnology, v. 16, p. 204-211.

Yakult, 2005. http://www.yakult.com.mx/lactobacilo.php

Bengmark,S, 1998, Ecological control of the gastrointestinal tract. The role of probiotic flora.: Gut, v. 42, p. 2-7.

Idem.

Ouwehand,A.C., M Derrien, W de Vos, K Tiihonen and N Rautonen, 2005, Prebiotics and other microbial substrates for gut functionality. : Current Opinion in Biotechnology, v. 16, p. 212-217.

Salminen,SP, et. al., Op. cit.

Dunne,C, L O'Mahony, L Murphy, G Thornton, D Morrissey, S O'Halloran, M Feeney, S Flynn, G Fitzgerald, C Daly, B Kiely, G C O'Sullivan, F Shanahan and J K Collins, 2001, In vitro selection criteria for probiotic bacteria of human origin: correlation with in vivo findings.: Am J Clin Nutr., v. 73 (suppl.), p. 386-392.

Stanton,C. et.al., Op.cit.

Chou,LS and B Weimer, 1999, Isolation and characterization of acid- and bile-tolerant isolates from strains oflactobacillus acidophilus.: J Dairy Sci., v. 82, p. 23-31.

Giannella, RA, S.A. Broitman and N. Zamchech 1972 Gastric acid barrier to ingested microorganisms in

man: studies in vivo and in vitro. Gut, 13: 251-256

Berrada,N, J F Lemeland, G Laroche, P Thouvenot and M Paia, 1991, Bifidobacterium from fermented milks: Survival during gastric transit.: J.Dairy Sci., v. 74, p. 409-413.

Chou,LS and B Weimer, Op. cit.

Gardiner,C, C Stanton, P B Lynch, J K Collins, G Fitzgeral and R P Ross 2005, Evaluation of Cheddar cheese as a food carrier for delivery of a probiotic strain to the gastrointestinal tract.: J Dairy Sci., v. 82, p. 1379-1387.

Bezkorovainy,A, 2001, Probiotics: determinants of survival and growth in the gut.: Am J Clin Nutr., v. 73(suppl.), p. 399-405.

Chou,LS and B Weimer, Op. cit.

Lankaputhra W.E.V. and N. P. Shah, 1995. Survival of Lactobacillus acidophilus and Bifidobacterium spp in the presence of acid and bile salts. Cult. Dairy Prod. J. 30:2–7.

Christiaens,H, R J Leer, P H Pouwels and W Verstraete, 1992, Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay.: Applied and Environmental Microbiology, v. 58(12), p. 3792-3798.

de Boever,P, R Wouters, L Verschaeve, P Berckmans, G Schoeters and W Verstraete, 2000, Protective effect of the bile salt hydrolase-active Lactobacillus reuteri against bile salt cytotoxicity.: Appl Microbiol Biotechnol., v. 53, p. 709-714.

Gilliland,SE, C R Nelson and C Maxwell, 1985, Assimilation of cholesterol by Lactobacillus acidophilus.: Applied and Environmental Microbiology, v. 49, p. 377-381.

Pereira,DIA, A L McCartney and G R Gibson, 2003, An in vitro study of the probiotic potential of a bile-salthydrolyzing Lactobacillus fermentum strain, and determination of its cholesterol-lowering properties.: Applied and Environmental Microbiology, v. 69(8), p. 4743-4752.

Stanton,C. et.al., Op.cit.

Merk,K, C Borelli and H C Korting, 2005, Lactobacilli – bacteria–host interactions with special regard to the urogenital tract.: International Journal of Medical Microbiology, v. 295, p. 9-18.

Chou,LS and B Weimer, Op. cit.

Fuller,R, 1991, Probiotics in human medicine.: Gut, v. 32, p. 439-442.

Reid,G, R L Cook and A W Bruce, 1987, Examination of strains of lactobacilli for properties that may influence bacterial interference in the urinary tract.: J.Urol., v. 138, p. 330-335.

Salminen,SP, et. al., Op. cit.

Hoepelman,AI and E I Tuomanen, 1992, Consequences of microbial attachment: directing host cell functions with adhesins.: Infection and Inmunity, v. 60, p. 1729-1733.

Salminen,SP, et. al., Op. cit.

Ouwehand,AC, et. al., Op. cit.

Tuomola,E, R Crittenden, M Playne, E Isolauri and S Salminen, 2001, Quality assurance criteria for probiotic bacteria.: Am J Clin Nutr., v. 73 (supl), p. 393-398.

Zoetendal, E., Wright, A., Vilpponen-Salmela, T., Ben-Amor, K., Akkermans, A. and W. de Vos. 2002. Mucosa associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from the faeces. Appl. Environ. Microbiol. 68: 3401–3407.

Chou,LS and B Weimer, Op. cit.

Stanton,C. et.al., Op.cit.

Gilliland,SE, et. al., Op. cit.

Hofmann,AF, G Molino, M Milanese and G Belforte, 1983, Description and simulation of a physiological pharmacokinetic model for the metabolism and enterohepatic circulation of bile acids in man. Cholic acid in healthy man.: J Clin Invest., v. 71, p. 1003-1022.

Fukushima,M and M Nakano, 1996, Effects of a mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on cholesterol metabolism in rats fed on a fat- and cholesterol-enriched

diet.: Br J Nutr., v. 76(6), p. 857-867.

de Smet,I, L Van Hoorde, M Vande Woestyne, H Christiaens and W Verstraete, 1995, Significance of bile salt hydrolytic activities of lactobacilli.: J Appl Bacteriol., v. 79, p. 292-301.

Pereira,DIA, et al., Op.cit.

Umeki, M, K Oue, S Mochizuki, Y Shirai and K Sakai, 2004, Effect of Lactobacillus rhamnosus KY-3 and cellobiose as synbiotics on lipid metabolism in rats.: J Nutr Sci Vitaminol, v. 50, p. 330-334.

Liong,MT and N P Shah, 2005 Optimization of cholesterol removal by probiotics in the presence of prebiotics by using a response surface method.: Applied and Environmental Microbiology, v. 71, p. 1745-1753.

Liong,MT and N P Shah, 2005. Optimization of cholesterol removal, growth and fermentation patterns ofLactobacillus acidophilus ATCC 4962 in the presence of mannitol, fructo-oligosaccharide and inulin: a response surface methodology approach.: J Appl Microbiol., v. 98, p. 1115-1126.

Pereira,DIA, et al., Op.cit.

Greany,KA, J A Nettleton, K E Wangen, W Thomas and M S Kurzer, 2004, Probiotic consumption does not enhace the cholesterol-lowering effect of soy in postmenopausal women.: J Nutr., v. 134, p. 3277-83.

Pereira,DI and G R Gibson, 2002, Effects of consumption of probiotics and prebiotics on serum lipid levels in humans.: Crit Rev Biochem Mol Biol, v. 37, p. 259-281.

Salminen,SP, et. al., Op. cit.

Kullen,MJ, M M Amann, M J O'Shaughnessy, D J O'Sullivan, F F Busta and L J Brady, 1997. Differentiation of ingested and endogenous bifidobacteria by DNA fingerprinting demonstrates the survival of an unmodified strain in the gastrointestinal tract of humans.: J Nutr., v. 127, p. 89-94.

Bezkorovainy,A, Op. cit.

Yakult, Op.cit

Stanton,C. et.al., Op.cit.

Lourens-Hattingh, A. and BC Viljoen 2001 Yogurt as probiotic carrier food. International Dairy Journal, 11 (1-2), p.1-17.

Sanders, ME and J. Huis in’t Veld 1999, Bringing a probiotic-containing functional food to the market: microbiological, product, regulatory and labeling issues. Antonie Van Leeuwenhoek, v. 76(1-4), p. 293-315.

Salminen,SP, et. al., Op. cit.

Bezkorovainy,A, Op. cit.

World Health Organization (WHO), 2005. Rising threat of heart disease and stroke as overweight and obesity rapidly increase. http://www.who.int/mediacentre/news/releases/2005/pr44/en/

Salminen,S, C Bouley, M C Boutron-Ruault, J H Cummings, A Franck, G R Gibson, E Isolauri, M C Mores, M Roberfroid and I Rowland 1998, Functional food science and gastrointestinal physiology and function.: Br J Nutr., v. 80, p. 147-171.

Tuomola,E., et.al., Op. cit

Merk,K, et.al., Op. cit.

Chou,LS and B Weimer, Op. cit.

Stanton,C. et.al., Op.cit.

Granato,D, G E Bergonzelli, R D Pridmore, L Marvin, M Rouvet and I E Corthesy-thelaz, 2004, Cell surface-associated elongation factor Tu mediates the attachment of Lactobacillus johnsonii NCC533 (La1) to human intestinal cells and mucin.: Infection and Inmunity, v. 72, p. 2160-2169

Published

2006-04-10

How to Cite

González Rivas, F., & González-Martínez, B. E. (2006). CRITERIOS DE CALIDAD DE LOS MICROORGANISMOS PROBIÓTICOS Y EVIDENCIAS SOBRE EFECTOS HIPOCOLESTEROLÉMICOS. RESPYN Revista Salud Pública Y Nutrición, 7(1). Retrieved from https://respyn.uanl.mx/index.php/respyn/article/view/162

Issue

Section

Artículo Original

Most read articles by the same author(s)