Effect of Omega-3 Fatty Acids on the Prevention of Sarcopenia in Older Adults: Systematic Review.
DOI:
https://doi.org/10.29105/respyn23.1-775Keywords:
Fatty acids omega 3, sarcopenia, agingAbstract
Sarcopenia, characterized by the loss of muscle mass, is a growing problem associated with global aging. Omega-3 fatty acids, known for their anti-inflammatory properties and benefits to cardiovascular and brain health, show potential in the prevention and treatment of sarcopenia, promoting muscle mass increase and reducing insulin resistance. Various studies suggest that omega-3 supplementation can significantly improve muscle strength and functionality in older adults, although its impact on lean tissue mass increase is not uniform. Some research also highlights the benefits of krill oil and formulas combining omega-3 with other nutrients, such as leucine and probiotics. However, the effectiveness of these supplements may vary according to individual factors like health status and overall diet. Although there is positive evidence on the benefits of omega-3 in improving muscle mass and function, more research is needed to fully understand these mechanisms. It is suggested that combining omega-3 with physical exercise, particularly resistance training, could be an effective strategy against sarcopenia in older adults.
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Alkhedhairi, S. A. A., Aba Alkhayl, F. F., Ismail, A. D., Rozendaal, A., German, M., MacLean, B., et al. (2022). The effect of krill oil supplementation on skeletal muscle function and size in older adults: A randomised controlled trial. Clinical Nutrition, 41, 1228–1235. Doi: 10.1016/j.clnu.2022.04.007. DOI: https://doi.org/10.1016/j.clnu.2022.04.007
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., ... & Visvanathan, R. (2013). Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. Journal of the American Medical Directors Association, 14(8), 542-559. Doi: 10.1016/j.jamda.2013.05.021. DOI: https://doi.org/10.1016/j.jamda.2013.05.021
Cornish, S. M., Cordingley, D. M., Shaw, K. A., Forbes, S. C., Leonhardt, T., Bristol, A., Candow, D. G., & Chilibeck, P. D. (2022). Effects of Omega-3 Supplementation Alone and Combined with Resistance Exercise on Skeletal Muscle in Older Adults: A Systematic Review and Meta-Analysis. Nutrients, 14(11), 2221. Doi: 10.3390/nu14112221. DOI: https://doi.org/10.3390/nu14112221
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., ... & Zamboni, M. (2019). Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing, 48(1), 16-31. Doi: 10.1093/ageing/afy169. DOI: https://doi.org/10.1093/ageing/afz046
Da Boit, M., Sibson, R., Sivasubramaniam, S., Meakin, J. R., Greig, C. A., Aspden, R. M., ... & Gray, S. R. (2017). Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: a randomized control trial. American Journal of Clinical Nutrition, 105(1), 151-158. Doi: 10.3945/ajcn.116.140780. DOI: https://doi.org/10.3945/ajcn.116.140780
Dalle, S., Van Roie, E., Hiroux, C., Vanmunster, M., Coudyzer, W., et al. (2021). Omega-3 Supplementation Improves Isometric Strength But Not Muscle Anabolic and Catabolic Signaling in Response to Resistance Exercise in Healthy Older Adults. The Journals of Gerontology: Series A, 76(3), 406–414. Doi: 10.1093/gerona/glaa309. DOI: https://doi.org/10.1093/gerona/glaa309
Dupont, J., Dedeyne, L., Dalle, S., Koppo, K., & Gielen, E. (2019). The role of omega-3 in the prevention and treatment of sarcopenia. Aging Clinical and Experimental Research, 31(6), 825–836. Doi: 10.1007/s40520-019-01146-1. DOI: https://doi.org/10.1007/s40520-019-01146-1
Dupont, J., Wauters, E., Dedeyne, L., Vercauteren, L., Amini, N., Lapauw, L., et al. (2023). Are dietary intake and nutritional status of specific polyunsaturated fatty acids correlated with sarcopenia outcomes in community-dwelling older adults with sarcopenia? – Exploratory results from ENHANce. BMC Geriatrics, 23, 272. Doi: 10.1186/s12877-023-04007-9. DOI: https://doi.org/10.1186/s12877-023-04007-9
Kunz, H. E., Michie, K. L., Gries, K. J., Zhang, X., Ryan, Z. C., & Lanza, I. R. (2022). A Randomized Trial of the Effects of Dietary n3-PUFAs on Skeletal Muscle Function and Acute Exercise Response in Healthy Older Adults. Nutrients, 14, 3537. Doi: 10.3390/nu14173537. DOI: https://doi.org/10.3390/nu14173537
Murphy, C. H., Flanagan, E. M., De Vito, G., Susta, D., Mitchelson, K. A. J., Marco Castro, E., et al. (2021). Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n–3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial. American Journal of Clinical Nutrition, 113, 1411–1427. Doi: 10.1093/ajcn/nqaa449. DOI: https://doi.org/10.1093/ajcn/nqaa449
Pahor, M., Anton, S., Beavers, D., Cauley, J. A., Fielding, R. A., et al. (2019). Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial. The Journals of Gerontology: Series A, 74(10), 1612–1619. Doi: 10.1093/gerona/gly277. DOI: https://doi.org/10.1093/gerona/gly277
Rodacki, C. L. N., Rodacki, A. L. F., Pereira, G., Naliwaiko, K., Coelho, I., Pequito, D., & Fernandes, L. C. (2012). Fish-oil supplementation enhances the effects of strength training in elderly women. American Journal of Clinical Nutrition, 95(2), 428-436. Doi: 10.3945/ajcn.111.021915. DOI: https://doi.org/10.3945/ajcn.111.021915
Rondanelli, M., Gasparri, C., Barrile, G. C., Battaglia, S., Cavioni, A., Giusti, R., et al. (2022). Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial. Nutrients, 14, 4566. Doi: 10.3390/nu14214566. DOI: https://doi.org/10.3390/nu14214566
Smith, G. I., Atherton, P., Reeds, D. N., Mohammed, B. S., Rankin, D., Rennie, M. J., & Mittendorfer, B. (2011). Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia–hyperaminoacidaemia in healthy young and middle-aged men and women. Clinical Science, 121(6), 267-278. Doi: 10.1042/CS20100597. DOI: https://doi.org/10.1042/CS20100597
Smith, G. I., Julliand, S., Reeds, D. N., Sinacore, D. R., Klein, S., & Mittendorfer, B. (2015). Fish oil–derived n−3 PUFA therapy increases muscle mass and function in healthy older adults. American Journal of Clinical Nutrition, 102(1), 115-122. Doi: 10.3945/ajcn.114.105833. DOI: https://doi.org/10.3945/ajcn.114.105833
Strandberg, E., Ponsot, E., Piehl-Aulin, K., Falk, G., & Kadi, F. (2019). Resistance Training Alone or Combined With N-3 PUFA-Rich Diet in Older Women: Effects on Muscle Fiber Hypertrophy. The Journals of Gerontology: Series A, 74(4), 489–493. Doi: 10.1093/gerona/gly130. DOI: https://doi.org/10.1093/gerona/gly130
Therdyothin, A., Phiphoptatsanee, N., & Isanejad, M. (2023). The Effect of Omega-3 Fatty Acids on Sarcopenia: Mechanism of Action and Potential Efficacy. Marine Drugs, 21(7), 399. Doi: 10.3390/md21070399. DOI: https://doi.org/10.3390/md21070399
Tseng, P. T., Zeng, B. Y., Zeng, B. S., Liao, Y. C., Stubbs, B., et al. (2023). Omega-3 polyunsaturated fatty acids in sarcopenia management: A network meta-analysis of randomized controlled trials. Ageing Research Reviews, 90, 102014. Doi: 10.1016/j.arr.2023.102014. DOI: https://doi.org/10.1016/j.arr.2023.102014
Úbeda, N., Achón, M., & Varela-Moreiras, G. (2012). Omega 3 fatty acids in the elderly. British Journal of Nutrition, 107(S2), 137–151. Doi: 10.1017/S0007114512001535. DOI: https://doi.org/10.1017/S0007114512001535
Xu, D., Lu, Y., Yang, X., Pan, D., Wang, Y., et al. (2022). Effects of fish oil-derived n-3 polyunsaturated fatty acid on body composition, muscle strength and physical performance in older people: a secondary analysis of a randomised, double-blind, placebo-controlled trial. Age and Ageing, 51, 1-9. Doi: 10.1093/ageing/afac274. DOI: https://doi.org/10.1093/ageing/afac274
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