RESISTENCIA A LA INSULINA Y SU CORRELACIÓN CON INTERLEUCINA-6 (IL-6) EN NIÑOS Y ADOLESCENTES DE SAN LUIS POTOSÍ (MEXICO)
Abstract
La resistencia a la insulina parece ser consecuencia de un estado de inflamación sistémica de bajo grado presente en la obesidad y en diabetes tipo 2. Actualmente se ha observado un incremento de obesidad y diabetes tipo 2 en población infantil y adolescente. El objetivo es conocer si existe asociación de resistencia a la insulina con niveles de IL-6 en población infantil seleccionada de manera aleatoria. Se incluyeron 184 niños (100 niñas) entre 6-12 años de edad, elegidos al azar de Escuelas de Educación Pública de la Ciudad de San Luís Potosí, México. Se evaluaron las medidas antropométricas: edad, peso, talla, IMC e ICC. Se tomaron muestras de sangre venosa, previo ayuno de 12 horas, para las determinaciones de glucosa, colesterol total, triglicéridos, lipoproteínas de alta y baja densidad (HDL-C) y (LDL-C). Las concentraciones de insulina se evaluaron por radioinmunoanálisis, se calculó el índice de resistencia a la insulina por el modelo homeostático HOMA-IR. Las concentraciones de IL-6 se realizaron por quimioluminiscencia. Los valores de IL-6 se encuentran asociados con los niveles de insulina (r = 0.144, p<0.051), colesterol (r = 0.145, p<0.052), IMC (r = 0.170, p<0.021), HDL-C (r = -0.180, p<0.01) y el HOMA-IR (r = 0.142, p<0.055). La cuantificación de IL-6 en
niños es útil para conocer desde edades tempranas el grado de inflamación asociado a la resistencia a la insulina en población mexicana.
Palabras clave: niños, obesidad, inflamación, interleucina 6
obesity, children, inflammation, interleukin 6
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