Serum IL-17, obesity, and metabolic risk in Mexican young adults

Celia Aradillas-García; Elizabeth Monreal-Escalante; Juan Manuel Vargas-Morlaes; Jorge Alegría-Torres; Sergio Rosales-Méndoza; Margarita Terán-García; Diana Patricia Portales-Pérez

doi:10.29105/respyn20.3-1

Authors

Celia Aradillas-García Autonomus University of San Luis Potosí https://orcid.org/0000-0003-3643-6992
Elizabeth Monreal-Escalante Autonomus University of San Luis Potosí https://orcid.org/0000-0002-2798-6151
Juan Manuel Vargas-Morlaes Autonomus University of San Luis Potosí
Jorge Alegría-Torres University of Guanajuato https://orcid.org/0000-0001-5875-6458
Sergio Rosales-Méndoza Autonomus University of San Luis Potosí
Margarita Terán-García University of Illinois at Urbana-Champaign https://orcid.org/0000-0002-8196-7605
Diana Patricia Portales-Pérez Autonomous University of San Luis Potosí https://orcid.org/0000-0001-8063-7869

DOI:

https://doi.org/10.29105/respyn20.3-1

Keywords:

IL-17, Metabolic risk, Obesity

Abstract

BACKGROUND: Obesity and several inflammatory pathways contribute to the development of metabolic diseases. Some pro-inflammatory cytokines and other signal proteins produced in fat and liver appear to propagate inflammation systemically. IL-17 is a pro-inflammatory cytokine secreted by activated T-cells. Upon binding to its receptor, IL-17 activates a cascade of signals that include MAPK, NF-kB and other pro- inflammatory cytokines. The aim of this study was to determine if the IL-17 levels are associated with obesity and its metabolic comorbidities in young adults. METHODS: Cross-sectional study in the UP AMIGOS 2009 cohort. Anthropometric measurement and blood samples were collected. Fasting glucose, insulin, and serum lipid profile was measured by conventional methods. Serum IL-17 was determined by ELISA assay in 102 individuals with obesity and overweight also in 306 lean students (aged 18 to 26 years old. RESULTS: Higher levels of IL-17 were found in the group with obesity (34.99 pg/mL) when compared to lean subjects (26.57 pg/mL). In addition, a positive correlation between serum IL-17 and body mass index and waist circumference in the group with obesity were detected. CONCLUSIONS: Increased IL-17 levels in young individuals with obesity and overweight are associated with risk factors for developing chronic metabolic diseases

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Alexandraki, K., Piperi,C., Kalofoutis, C., Singh, J., Alaveras, A., & Kalofoutis A. (2006). Inflammatory process in type 2 diabetes: The role of cytokines. Ann N Y Acad Sci, 1084:89-117. doi: 10.1196/annals.1372.039. DOI: https://doi.org/10.1196/annals.1372.039

Baker, J.L., Olsen, L.W & Sørensen, T.I.A. (2008).Childhood body mass index and the risk of coronary heart disease in adulthood. Ugeskrift for laeger, 170(33):2434-37.

Balistreri, C.R., Caruso, C., & Candore G. (2010). The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators of inflamm, 2010:802078. doi: 10.1155/2010/802078. DOI: https://doi.org/10.1155/2010/802078

Calabro, P., & Yeh, E.T. (2007). Obesity, inflammation, and vascular disease: the role of the adipose tissue as an endocrine organ. Subcell BIochem, 42:63-91. DOI: https://doi.org/10.1007/1-4020-5688-5_3

Chen, Z., & O’Shea J.J. (2008). Th17 cells: a new fate for differentiating helper T cells. Immunol res, 41(2):87-102. doi: 10.1007/s12026-007-8014-9. DOI: https://doi.org/10.1007/s12026-007-8014-9

Dandona, P., Aljada A., & Bandyopadhyay A. (2004). Inflammation: the link between insulin resistance, obesity and diabetes. Trends in Immunol, 25(1):4-7. DOI: https://doi.org/10.1016/j.it.2003.10.013

Donath, M.Y., & Shoelson S.E. (2011). Type 2 diabetes as an inflammatory disease. Nat Rev Immunol, 11(2):98-107. doi: 10.1038/nri2925. DOI: https://doi.org/10.1038/nri2925

Donner, C. C., Fraze, E., Chen, YD., Hollenbeck C.B., Foley JE., & Reaven GM. (1985). Presentation of a new method for specific measurement of in vivo insulin-stimulated glucose disposal in humans: comparison of this approach with the insulin clamp and minimal model techniques. J Clinic Endocrinol Metab, 60(4):723-26. doi: 10.1210/jcem-60-4-723. DOI: https://doi.org/10.1210/jcem-60-4-723

Esposito, K., Giugliano, G., Scuderi, N., & Giugliano D. (2006). Role of adipokines in the obesity-inflammation relationship: the effect of fat removal. Plast Reconstr Surg, 118(4):1048-57; discussion 1058-9. doi: 10.1097/01.prs.0000232281.49432.ce. DOI: https://doi.org/10.1097/01.prs.0000232281.49432.ce

Ferrante, A.W. (2007). Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med, 262(4):408-14. doi: 10.1111/j.1365-2796.2007.01852.x. DOI: https://doi.org/10.1111/j.1365-2796.2007.01852.x

Fouser, L.A., Wright, J.F., Dunussi-Joannopoulos, K., & Collins, M. (2008). Th17 cytokines and their emerging roles in inflammation and autoimmunity. Immunol Rev, 226:87-102. doi: 10.1111/j.1600-065X.2008.00712.x. DOI: https://doi.org/10.1111/j.1600-065X.2008.00712.x

Franks, P.W., Hanson, R.L., Knowler, W.C., Sievers, M.L., Bennett P.H., & Looker H.C. (2010). Childhood obesity, other cardiovascular risk factors, and premature death. Engl J Med, 362(6):485-93. doi: 10.1056/NEJMoa0904130. DOI: https://doi.org/10.1056/NEJMoa0904130

Galgani, M., & Matarese, G. (2010). Editorial: acute inflammation in obesity: IL-17A in the middle of the battle. J Leukoc Biol, 87(1):17-18. doi: 10.1189/jlb.0809530. DOI: https://doi.org/10.1189/jlb.0809530

Gregor, M.F., & Hotamisligil, G.S. (2011). Inflammatory mechanisms in obesity. Annu Rev Immunol, 29:415-45. doi: 10.1146/annurev-immunol-031210-101322. DOI: https://doi.org/10.1146/annurev-immunol-031210-101322

Hotamisligil, G.S. (2006). Inflammation and metabolic disorders. Nat, 444(7121):860-67. doi: 10.1038/nature05485. DOI: https://doi.org/10.1038/nature05485

Kim, J., Bhattacharjee, R., Kheirandish-Gozal, L., Khalyfa, A., Capdevila, O.S., Tauman, R &., Gozal, D. (2010). Insulin sensitivity, serum lipids, and systemic inflammatory markers in school-aged obese and nonobese children. Int J Pediatr, 2010:846098. doi: 10.1155/2010/846098. DOI: https://doi.org/10.1155/2010/846098

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V.K. (2009). IL-17 and Th17 Cells. Annu Rev Immunol, 27:485-517. doi: 10.1146/annurev.immunol.021908.132710. DOI: https://doi.org/10.1146/annurev.immunol.021908.132710

Korn, T., Oukka, M., Kuchroo V., & Bettelli, E. (2007). Th17 cells: effector T cells with inflammatory properties. Semin Immunol, 19(6):362-71. doi: 10.1016/j.smim.2007.10.007. DOI: https://doi.org/10.1016/j.smim.2007.10.007

Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., & Turner R.C. (1985). Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7):412-19. DOI: https://doi.org/10.1007/BF00280883

Ouyang, W., Kolls, J.K., & Zheng, Y (2008). The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity, 28(4):454-67. doi: 10.1016/j.immuni.2008.03.004. DOI: https://doi.org/10.1016/j.immuni.2008.03.004

Pini, M., & Fantuzzi, G. (2010). Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice. J Leukoc Biol, 87(1):51-58. doi: 10.1189/jlb.0309188. DOI: https://doi.org/10.1189/jlb.0309188

Qu, Y., Zhang, Q., Ma, S., Liu, S.,Chen, Z., Mo, Z., & You, Z. (2016). Interleukin-17A differentially induces inflammatory and metabolic gene expression in the adipose tissues of lean and obese mice». Int J Mol Sci, 17(4):1-16. doi: 10.3390/ijms17040522. DOI: https://doi.org/10.3390/ijms17040522

Ribeiro, S.M.T.L., Lopes, L.R., Paula Costa, G de., Figueiredo, V.P., Shrestha, D., Batista, A.P., et al. (2017). CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women. Immun Ageing, 14(1):1-7. doi: 10.1186/s12979-017-0089-0. DOI: https://doi.org/10.1186/s12979-017-0089-0

Santos, M.G dos., Pegoraro, M., Sandrini, F., & Macuco, E.C. (2008). Risk factors for the development of atherosclerosis in childhood and adolescence. Arq Bras Cardiol, 90(4):276-83. DOI: https://doi.org/10.1590/S0066-782X2008000400012

Shin, J.H., Shin, D.W., & Noh, M. (2009). Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes. Biochem Pharmacol, 77(12):1835-44. doi: 10.1016/j.bcp.2009.03.008. DOI: https://doi.org/10.1016/j.bcp.2009.03.008

Skrha, J. (2010). Type 2 diabetes mellitus as a subclinical inflammation. (2010) Cas Lek Cesk, 149(6):277-81.

Sumarac-Dumanovic, M., Stevanovic, D., Ljubic, A., Jorga, J., Simic, M., Stamenkovic-Pejkovic, D., et al. (2009). Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women. Int J Obes, 33(1):151-56. doi: 10.1038/ijo.2008.216. DOI: https://doi.org/10.1038/ijo.2008.216

Tarantino, G., Costantini, S., Finelli, C., Capone, F., Guerriero, E., La Sala, N., et al. (2014). Is serum Interleukin-17 associated with early atherosclerosis in obese patients? J Transl Med, 12(1):1-10. doi: 10.1186/s12967-014-0214-1. DOI: https://doi.org/10.1186/s12967-014-0214-1

Ten, S., & Maclaren, N. (2004). Insulin resistance syndrome in children. J Clin Endocrinol Metabol, 89(6):2526-39. doi: 10.1210/jc.2004-0276. DOI: https://doi.org/10.1210/jc.2004-0276

Wellen, K.E., & Hotamisligil, GS. (2005). Inflammation, stress, and diabetes. J Clin Invest, 115(5):1111-19. doi: 10.1172/JCI25102. DOI: https://doi.org/10.1172/JCI25102

Wilson, N.J., Boniface, K., Chan, J.R., McKenzie, B.S., Blumenschein, W.M., Mattson, J.D., et al. (2007). Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol, 8(9):950-57. doi: 10.1038/ni1497. DOI: https://doi.org/10.1038/ni1497

Zúñiga, L.A.,Shen W., Joyce-shaikh, B., Pyatnova, E.a., Richards, A.G., Thom, C., et al. (2011). NIH Public Access. Obesity, 185(11):6947-59. doi: 10.4049/jimmunol.1001269.IL-17. DOI: https://doi.org/10.4049/jimmunol.1001269