IL-17 serico, obesidad y riesgo metabolico en adultos jovenes mexicanos.

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DOI:

https://doi.org/10.29105/respyn20.3-1

Palabras clave:

IL-17, Riesgo metabólico, Obesidad

Resumen

Introducción: La obesidad y vías inflamatorias contribuyen al desarrollo de enfermedades metabólicas. La masa grasa e hígado producen citoquinas proinflamatorias que pudieran promover la inflamación sistémica. La IL-17 es una citoquina proinflamatoria secretada por células T activadas. Cuando la IL-17 se une al receptor, se activa una casada de señales incluidas MAPK, NFkB y otras citoquinas proinflamatorias. Objetivo: Determinar si los niveles IL-17 están asociados con la obesidad y sus comorbilidades en adultos jóvenes. Método:  Un estudio transversal del estudio de cohorte UP AMIGOS 2009. Se tomaron medidas antropométricas y muestras de sangre. Se midió glucosa en ayuno, insulina y perfil lipídico. La IL-17 en suero se determinó por la prueba ELISA en 102 individuos con obesidad o sobrepeso y en 306 con normopeso de 18 a 26 años de edad.  Resultados: Se encontraron mayores cifras de IL-17 en el grupo con obesidad (34.99 pg/mL) que en el de normopeso (26.57 pg/mL). Se observó una relación positiva entre IL-17 y el índice de masa corporal y circunferencia de cintura en el grupo con obesidad. Conclusiones: Niveles elevados de IL-17 en adultos jóvenes con sobrepeso u obesidad se asocian con factores de riesgo para el desarrollo de enfermedades crónicas.

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2021-07-01

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Aradillas-García, C., Monreal-Escalante, E., Vargas-Morlaes, J. M., Alegría-Torres, J., Rosales-Méndoza, S., Terán-García, M., & Portales-Pérez, D. P. (2021). IL-17 serico, obesidad y riesgo metabolico en adultos jovenes mexicanos . RESPYN Revista Salud Pública Y Nutrición, 20(3), 1–7. https://doi.org/10.29105/respyn20.3-1

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