Asociación entre concentraciones de ferritina, CRP, sTFR Y HbA1c en sujetos con y sin DM2.
DOI:
https://doi.org/10.29105/respyn19.3-2Keywords:
Diabetes tipo 2, proteína c- reactiva, ferritina.Abstract
Introducción: Se ha demostrado que existe un componente inflamatorio en la patogenia de la diabetes tipo 2 (DM2) y se ha asociado con elevaciones en los niveles de ferritina sérica. El objetivo fue evaluar la asociación entre concentraciones séricas de ferritina, CRP, receptores solubles de transferrina (sTfR) y hemoglobina glucosilada (HbA1c) en sujetos con y sin diabetes tipo 2. Metodología: Estudio secundario, derivado de la ENSANUT 2006. Se analizaron concentraciones de ferritina, sTFR y CRP (n=4578), se asoció HbA1c y ferritina (n=287), y variables como, índice de masa corporal (IMC), edad, sexo, tratamiento actual para DM2, tabaquismo y consumo de alcohol. El análisis estadístico se realizó con modelos de regresión logística múltiple y modelos de regresión lineal múltiple. Se consideró como significancia estadística un valor de p <0.05 y la dirección y magnitud de la asociación. Resultados: La posibilidad de tener DM2 se asoció con las concentraciones séricas de ferritina y con las de CRP (p<0.02). La ferritina se asoció de manera inversa con las de sTFR (β -0.91, p<0.001). La HbA1c no se asoció con la ferritina. Conclusiones: En mexicanos con DM2 la ferritina sérica es mayor que en sujetos sin diabetes y su variabilidad está explicada por indicadores del estatus de hierro y de inflamación.
Palabras clave: Diabetes tipo 2, inflamación, proteína c- reactiva, ferritina.
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Akter, S., Nanri, A., Kuwahara, K., Matsushita, Y., Nakagawa, T., & Konishi, M. et al. (2017). Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals. Journal Of Diabetes Investigation, 8(4), 462-470. doi: 10.1111/jdi.12617 DOI: https://doi.org/10.1111/jdi.12617
Canturk, Z., Çetinarslan, B., Tarkun, İ., & Zafer Canturk, N. (2003). Serum Ferritin Levels in Poorly‐ and Well‐Controlled Diabetes Mellitus. Endocrine Research, 29(3), 299-306. doi: 10.1081/erc-120025037 DOI: https://doi.org/10.1081/ERC-120025037
Carrillo E., Peña P., Zepeda M. (2015). Ferritina y síndrome hiperferritinémico. Su impacto en el enfermo grave; conceptos actuales. Med Crit. 2015;29(3),157-166.
Dehghan A., Hoek M., Sijbrands E., Stijnen T., Witteman J., & Hofman A. (2007). Risk of type 2 diabetes attributable to c-reactive protein and other risk factors. Diabetes Care, 30:2695-2699. DOI: https://doi.org/10.2337/dc07-0348
Doi Y., Kiyohara Y., Kubo M., Ninomiya T., Wakugwa Y.,& Yonemoto K. (2005). Elevated c-reactive protein is a predictor of the development of diabetes in a general japanese population. Diabetes Care, 28:2497-2500. doi: 10.2337/diacare.28.10.2497 DOI: https://doi.org/10.2337/diacare.28.10.2497
Eshed, I., Elis, A., & Lishner, M. (2001). PLASMA FERRITIN AND TYPE 2 DIABETES MELLITUS: A CRITICAL REVIEW. Endocrine Research, 27(1-2), 91-97. doi: 10.1081/erc-100107172 DOI: https://doi.org/10.1081/ERC-100107172
Fernandez-Real, J., Lopez-Bermejo, A., & Ricart, W. (2002). Crosstalk Between Iron Metabolism and Diabetes. Diabetes, 51(8), 2348-2354. doi: 10.2337/diabetes.51.8.2348 DOI: https://doi.org/10.2337/diabetes.51.8.2348
Ford, E., & Cogswell, M. (1999). Diabetes and serum ferritin concentration among U.S. adults. Diabetes Care, 22(12), 1978-1983. doi: 10.2337/diacare.22.12.1978 DOI: https://doi.org/10.2337/diacare.22.12.1978
Forouhi, N., Harding, A., Allison, M., Sandhu, M., Welch, A., & Luben, R. et al. (2007). Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study. Diabetologia, 50(5), 949-956. doi: 10.1007/s00125-007-0604-5 DOI: https://doi.org/10.1007/s00125-007-0604-5
Fumeron F., P’ean F., Pharmd F., & Balkau B. (2006). Ferritin and Transferrin Are Both Predictive of the Onset of Hyperglycemia in Men and Women Over 3 Years. Diabetes Care, 29:2090–2094. DOI: https://doi.org/10.2337/dc06-0093
Hu F., Meigs J., Li T., Rifai N., & Manson J. (2004). Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes, 53:693-700. doi: 10.2337/diabetes.53.3.693 DOI: https://doi.org/10.2337/diabetes.53.3.693
Jehn, M. L., Guallar, E., Clark, J. M., Couper, D., Duncan, B. B., Ballantyne, C. M., et al. (2005). A prospective study of plasma ferritin level and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study. Am. J. Epidemiol, 165(9): 1047–54. DOI: https://doi.org/10.1093/aje/kwk093
Jiang, R. (2004). Body Iron Stores in Relation to Risk of Type 2 Diabetes in Apparently Healthy Women. JAMA, 291(6), 711. doi: 10.1001/jama.291.6.711 DOI: https://doi.org/10.1001/jama.291.6.711
Ma, H., Lin, H., Hu, Y., Li, X., He, W., & Jin, X. et al. (2018). Serum ferritin levels are associated with insulin resistance in Chinese men and post-menopausal women: the Shanghai Changfeng study. British Journal Of Nutrition, 120(8), 863-871. doi: 10.1017/s0007114518002167 DOI: https://doi.org/10.1017/S0007114518002167
O’Rourke, R. (2009). Molecular Mechanisms of Obesity and Diabetes: At the Intersection of Weight Regulation, Inflammation, and Glucose Homeostasis. World Journal Of Surgery, 33(10), 2007-2013. doi: 10.1007/s00268-009-0067-6 DOI: https://doi.org/10.1007/s00268-009-0067-6
Pickup, J. (2004). Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes. Diabetes Care, 27(3), 813-823. doi: 10.2337/diacare.27.3.813 DOI: https://doi.org/10.2337/diacare.27.3.813
Pietrangelo A. (2004). Hereditary Hemochromatosis- A new look at an old disease. N Engl J Med, 350:2383-2397. doi: 10.1056/NEJMra031573 DOI: https://doi.org/10.1056/NEJMra031573
Pietrangelo A. (2010). Hereditay Hemochromatosis: Pathogenesis, Diagnosis, and treatment. Gastroenterology,139(2):393-408,408.e12. doi:10.1053/j.gastro.2010.06.013. DOI: https://doi.org/10.1053/j.gastro.2010.06.013
Pradham A., Manson J., Rifai N., Buring J., & Ridker P. (2001). C-reactive protein, Interleukin 6 and risk developing type 2 diabetes mellitus. JAMA, 286:327-334. doi: 10.1001/jama.286.3.327 DOI: https://doi.org/10.1001/jama.286.3.327
Rajpathak, S. N., Wylie-Rosett, J., Gunter, M. J., Negassa, A., Kabat, G. C., Rohan, T. E., et al. (2009). Biomarkers of body iron stores and risk of developing type 2 diabetes. Diab Obes. Metab, 11(5), 472–9. DOI: https://doi.org/10.1111/j.1463-1326.2008.00985.x
Rojas-Martínez, R., Basto-Abreu, A., Aguilar-Salinas, C., Zárate-Rojas, E., Villalpando, S., & Barrientos-Gutiérrez, T. (2018). Prevalencia de diabetes por diagnóstico médico previo en México. Salud Pública De México, 60(3, may-jun), 224. doi: 10.21149/8566 DOI: https://doi.org/10.21149/8566
Salonen J., Tuomainen T., Nyyssönen K., Lakka H., & Punnonen K. (1998). Relation between iron stores and noninsulin dependent diabetes in men: casecontrol study. BMJ, 317(7160): 727–730. DOI: https://doi.org/10.1136/bmj.317.7160.727
Shamah-Levy T., Villalpando-Hernández S., & Rivera-Dommarco JA. (2007). Resultados de Nutrición de la ENSANUT 2006. Cuernavaca, México: Instituto Nacional de Salud Pública.
Shamah- Levy T,. Villalpando- Hernández S., &Rivera-Dommarco J. (2006). Manual de Procedimientos para Proyectos de Nutrición. Cuernavaca, México. Instituto Nacional de Salud Pública.
Sharifi F., & Sazandeh S. (2004). Serum ferritin in type 2 diabetes mellitus and its relationship with HbA1c. Acta Med Iranica, 42(2): 142-145.
Son N. (2019). Influence of ferritin levels and inflammatory markers on HbA1c in the Type 2 Diabetes mellitus patients. Pak J Med Sci, 35(4), 1030-1035. doi: https://doi.org/10.12669/pjms.35.4.1003 DOI: https://doi.org/10.12669/pjms.35.4.1003
Sun, L., Zong, G., Pan, A., Ye, X., Li, H., Yu, Z., et al. (2013). Elevated plasma ferritin is associated with increased incidence of type 2 diabetes in middle-aged and elderly Chinese adults. J. Nutr, 143(9), 1459–65. DOI: https://doi.org/10.3945/jn.113.177808
Swaminathan, S., Fonseca, V., Alam, M., & Shah, S. (2007). The Role of Iron in Diabetes and Its Complications. Diabetes Care, 30(7), 1926-1933. doi: 10.2337/dc06-2625 DOI: https://doi.org/10.2337/dc06-2625
Twetz NW (1999). Textbook of Clinical Chemistry (pp. 794-795). Philadelphia: Saunders.
Van den Oever, I., Raterman, H., Nurmohamed, M., & Simsek, S. (2010). Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus. Mediators Of Inflammation, 2010, 1-15. doi: 10.1155/2010/792393 DOI: https://doi.org/10.1155/2010/792393
Villalpando S., Rojas R., Shaman-Levy T., Avila M., Gaona B., De la Cruz V., Rebollar R., & Hernandez L. (2010). Prevalence and distribution of type 2 Diabetes mellitus in Mexican adult population. A probabilistic survey. Salud Publ Mex, 52(1): S19-S26. DOI: https://doi.org/10.1590/S0036-36342010000700005
World Health Organization. Obesity: Preventing and managing the Global Epidemic. WHO technical Report Series 2000;894. [consultado 23/01/20]. Disponible en: https://www.who.int/nutrition/publications/obesity/WHO_TRS_894/en/
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