Effect of maternal cafeteria diet consumption on the gut microbiota of male offspring
DOI:
https://doi.org/10.29105/respyn24.3-886Keywords:
microbiota intestinal, dieta materna, programación fetalAbstract
Introduction: Lifestyle and diet are among the most influential factors shaping the composition of the gut microbiota, potentially programming offspring toward the development of diseases in adulthood. Objective: To evaluate the effect of maternal cafeteria diet consumption during the perinatal period on body weight, dietary intake, and gut microbiota in male C57BL/6 mice offspring. Material and method: Female C57BL/6 mice were fed either a standard or cafeteria diet throughout the perinatal period (9 weeks). After weaning (day 21), ten male offspring per group were selected and maintained on a control diet until week 8, when fecal samples were collected for microbiota analysis. Results: The cafeteria group exhibited lower food intake and body weight compared to the control group. A significant increase in Parabacteroides distasonis, Mucispirillum schaedleri, and Lactobacillus reuteri, and a decrease in Akkermansia muciniphila were observed in the cafeteria group. Moreover, weight gain was negatively correlated with the abundance of Rikenella and Mucispirillum. Conclusion: These findings suggest that maternal consumption of a cafeteria-style diet may program the gut microbiota composition of the offspring.
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Copyright (c) 2025 Heriberto Castro García, Yvanna Guadalupe Jiménez Gaytán, Vania Urias Orona, Sonia Leticia Ramírez Garza
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