Efecto del consumo materno de una dieta de cafetería sobre la microbiota intestinal en la descendencia macho
DOI:
https://doi.org/10.29105/respyn24.3-886Palabras clave:
microbiota intestinal, dieta materna, programación fetalResumen
Introducción: Algunos de los factores más importantes que determinan la composición de la microbiota intestinal son el estilo de vida y la alimentación, programando a la descendencia al desarrollo de enfermedades en la edad adulta. Objetivo: Evaluar el efecto del consumo materno de una dieta de cafetería durante la etapa perinatal en ratones C57BL/6 macho sobre la microbiota intestinal en su peso, ingesta dietética y microbiota intestinal. Material y Método: Ratones hembra C57BL/6 fueron alimentados con dieta estándar y de cafetería durante la etapa perinatal (9 semanas). Tras el destete (día 21), se seleccionaron 10 crías macho por grupo y se mantuvieron con dieta control hasta la semana 8, momento en que se recolectaron muestras fecales para análisis de microbiota. Resultados: El grupo cafetería presentó menor ingesta y peso corporal comparado con el control. Se observó un aumento significativo de Parabacteroides distasonis, Mucispirillum schaedleri y Lactobacillus reuteri, y una reducción de Akkermansia muciniphila en el grupo cafetería. Además, la ganancia de peso se correlacionó negativamente con la abundancia de Rikenella y Mucispirillum. Conclusión: Los datos obtenidos sugieren que la ingesta materna de una dieta de tipo cafetería podría causar un efecto de programación a nivel de microbiota intestinal en la descendencia.
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Derechos de autor 2025 Heriberto Castro García, Yvanna Guadalupe Jiménez Gaytán, Vania Urias Orona, Sonia Leticia Ramírez Garza
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